Ductal carcinoma in situ breast

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What is DCIS? What are the symptoms of DCIS? How is DCIS diagnosed? How is DCIS graded? Can DCIS develop into invasive breast cancer?
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The Who, What, Where, When and Sometimes, Why.

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Ductal carcinoma in situ (DCIS) - Symptoms and causes - Mayo Clinic

Evidence shows that high-grade DCIS is an aggressive subtype with an overall poorer prognosis than non-high-grade disease. There have been many studies evaluating the role of the radiologist in the diagnosis of high-grade DCIS with emphasis on radiologic-pathologic correlation using standard mammography and magnetic resonance imaging. Our current understanding of the clinical importance of high-grade DCIS from the perspective of a radiologist and characteristic imaging features are discussed in detail. The diagnosis of DCIS has increased dramatically over the last several decades from an incidence of less than 2 per , in the early s to Some advocates of screening see this as a victory, achieving one of the goals of a screening program: the prevention of life threatening invasive cancer by detection and treatment at the in situ stage.
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Ductal carcinoma in situ (DCIS)

Abstract Background Ductal carcinoma in situ DCIS is a non-invasive form of early breast cancer, with a poorly understood natural history of invasive transformation. Necrosis is a well-recognized adverse prognostic feature of DCIS, and non-invasive detection of its presence and spatial extent could provide information not obtainable by biopsy. We describe here imaging of the distribution and extent of comedo-type necrosis in a model of human DCIS using C2Am, an imaging agent that binds to the phosphatidylserine exposed by necrotic cells.
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The ducts of the breast are lined with two layers of cells. When these cells multiply abnormally, cancer cells in the duct can develop. Cancer in the duct is called ductal carcinoma in situ DCIS. As long as the cancer cells stay inside the duct, DCIS has no risk of spreading.
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